Youhei Sohma, A. Taniguchi, M. Skwarczynski
May 1, 2006
Citations
0
Influential Citations
54
Citations
Journal
Tetrahedron Letters
Abstract
A novel 'O-acyl isodipeptide unit', Boc-Thr(Fmoe-Val)-OH 5 has been successfully used for the efficient synthesis of a difficult sequence-containing pentapeptide based on the 'O-acyl isopeptide method', in which racemization-inducible esterification could be omitted, suggesting that the use Of O-acyl isodipeptide units allows the application of this method to fully automated protocols for the synthesis of long peptides or proteins. (c) 2006 Elsevier Ltd. All rights reserved.