L. Li-na
2010
Citations
0
Influential Citations
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Citations
Quality indicators
Journal
Journal of Nanjing University of Traditional Chinese Medicine
Abstract
OBJECTIVE The purpose of this research is to observe the curative effect of Wu Ji San and small dose Clomifene Citrate on PCOS with sterility.METHOD 80 PCOS patients were divided randomly into treatment group(Clomifene Citrate) and control group(Wu Ji San and Clomifene Citrate).After 1 to 3 months treatment,the changes of the following items would be observed:testosterone(T),Follicular Stimulating Hormone(FSH),luteinizing hormone(LH),fasting insulin(FINS),Insulin(INS) 2 hours after meal,follicular development,the changes of endometrium thickness.Additionally,the occurrence of ovarian hyperstimulation,Ovulation rate and pregnancy rate were detected.RESULT In the treatment group,18 cases were cured,14 cases got better,the overall response rate was 80.00%;while in the control group,18 cases cured and 14 got better,the overall response rate was 60.00%,comparing the treatment group with the control group,P0.05.By injecting HCG,the endometrium thickness of the treatment group is apparently thicker than that of the control group(P0.01).2 cases of ovarian hyperstimulation occurred in the control group,none in the treatment group.In the treatment group,the Insulin resistance and serum testosterone experienced a dramatic change before and after treatment(P0.05).There was no statistical difference in the control group(P0.05).CONCLUSION Wu Ji San,together with Clomifene Citrate,is able to reduce the side effect of Clomifene Citrate and increase its sensitivity,thus effectively increasing pregnancy rate.