J. D. Valk, H. Plas, J. Bode
Sep 2, 2010
Citations
0
Influential Citations
8
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Journal
Recueil des Travaux Chimiques des Pays-Bas
Abstract
Evidence is presented that the amination of 4-chloro-2,6-diphenylpyrimidine with potassium amide in liquid ammonia into the corresponding 4-amino compound occurs to the extent of about 45% by the ANRORC mechanism. In the amination of the 4-iodo- and 4-fluoro derivatives of 2,6-diphenylpyrimidine, however, the ANRORC mechanism is not operative at all. The amination of 5-bromo-4-chloro-2,6-diphenylpyrimidine into 4-amino-5-bromo-2,6-diphenylpyrimidine occurs to the extent of about 18% by the ANRORC mechanism. The synthesis of 5-bromo-4-chloro-2,6-diphenyl-[1(3)-15N]pyrimidine and of the 4-fluoro, 4-chloro and 4-iodo derivatives of 2,6-diphenyl-[1(3)-15N]pyrimidine is described.