Tadashi Ogawa, Masumi Kimoto, Kei Sasaoka
Oct 29, 1987
Citations
5
Influential Citations
156
Citations
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Journal
Biochemical and biophysical research communications
Abstract
An enzyme concerned with the degradation of NG,NG-dimethyl-L-arginine to L-citrulline was investigated in rats. The enzyme purified from rat kidney catalyzed the direct conversion of NG,NG-dimethyl-L-arginine to L-citrulline with liberation of dimethylamine from the methylated guanidino moiety. The reaction required no co-factor and the maximum activity was obtained at pH 6.5. The enzyme was highly specific for NG,NG-dimethyl-L-arginine.