M. Wilkinson, R. Powis
Nov 1, 2011
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Influential Citations
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Quality indicators
Journal
Contact Dermatitis
Abstract
A 50-year-old woman developed an extensive urticated rash following the use of a cosmetic skin serum applied to her limbs and trunk. The reaction developed within 2 hr of application, and persisted for 48 hr after removal. Its distribution corresponded with the areas of application. The patient had previously experienced similar reactions after using certain brands of soap and laundry detergent. Patch testing with a baseline, photo-patch, facial and fragrance series together with her own products was carried out. There was a positive reaction to the serum (as is) read at D2 (+) and D4 (+), which was reproducible on repeat testing. Tests in twenty controls gave negative results. Patch testing with individual constituents of the serum produced a reaction to octyldodecyl xyloside 6% in petrolatum (pet.) (−/+). Tests in 20 controls gave negative results. The supplied octyldodecyl xyloside was noted to be a mixture containing octyldodecanol 60%, octyldodecyl xyloside 20%, and polyethylene glycol (PEG)-30 dipolyhydroxystearate 20%. Octyldodecyl xyloside was only available as part of a blend with octyldodecanol; therefore, further patch testing involved testing a dilution series of pure octyldodecanol 0.5%, 1%, 5% and 10% in pet., a dilution series of pure PEG-30 dipolyhydroxystearate 1.5%, 3%, 15% and 30% in pet., and a dilution series of octyldodecyl