M. Adib, Helia Janatian Ghazvini, Mehdi Soheilizad
Aug 1, 2015
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0
Influential Citations
15
Citations
Journal
Helvetica Chimica Acta
Abstract
A one-pot four-component synthesis of thieno[2,3-d]pyrimidin-4-amines via sequential Gewald/cyclocondensation reactions is described. 2-Aminothiophene-3-carbonitriles obtained from the Gewald reaction between cyclic ketones, malononitrile, and sulfur underwent a condensationcyclization reaction with benzonitriles under solvent-free conditions to afford the title compounds in excellent yields.