S. Fukamachi, H. Konishi, K. Kobayashi
Jun 1, 2011
Citations
0
Influential Citations
5
Citations
Journal
Helvetica Chimica Acta
Abstract
An efficient method for the preparation of 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepine derivatives under mild conditions has been developed. The reaction of 2-(2-aminophenyl)ethanols 1 with acid chlorides in the presence of excess Et3N in THF at room temperature gave the corresponding N-acylated intermediates 2, which were dehydrated by treatment with POCl3 to give 2-substituted 4-aryl-4,5-dihydro-3,1-benzoxazepines 3 in a one-pot reaction.