G. Odasso, E. Toja
Oct 1, 1983
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Influential Citations
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Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A one-pot synthesis of 3-(1-methylethyl)-2-(4-methoxyphenyl)-3H-naphth[1,2-d] [2-14C]imidazole (1), a nonacidic antiinflammatory and analgesic agent, is described. The starting material, 2-isopropylamino-1-nitronaphthalene (3) was hydrogenated, the resulting diamine (4) reacted with p-[carbonyl-14C] anisaldehyde and the intermediate imidazoline (5) finally dehydrogenated to give (1) in a radiochemical yield of 63.4% with a radiochemical purity > 99%. The labelled compound has been used in pharmacokinetics and metabolism studies.