Wenyong Han, Zunting Zhang, Ying-Chun Zhang
Aug 1, 2010
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Journal
Helvetica Chimica Acta
Abstract
A simple and straightforward methodology toward the synthesis of novel 1-(4,5-diphenylpyrimidin- 2-yl)thiourea has been developed by a one-step reaction of isoflavones with amidinothiourea. A series of 16 new compounds was synthesized. All compounds were characterized by FT-IR, NMR, and elemental analysis. The structure of a typical compound was established by X-ray diffraction. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery.