F. Mathias, Youssef Kabri, L. Okdah
Aug 1, 2017
Citations
0
Influential Citations
7
Citations
Journal
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Abstract
A one-pot regioselective bis-Suzuki-Miyaura or Suzuki-Miyaura/Sonogashira reaction on 2,4-dibromo-1-methyl-5-nitro-1H-imidazole under microwave heating was developed. This method is applicable to a wide range of (hetero)arylboronic acids and terminal alkynes. Additionally, this approach provides a simple and efficient way to synthesize 2,4-disubstituted 5-nitroimidazole derivatives with antibacterial and antiparasitic properties.