G. C. Reddy, V. Chandregowda, G. Rao
2007
Citations
0
Influential Citations
23
Citations
Journal
Heterocycles
Abstract
A simple and efficient one-pot conversion of 2-nitrobenzonitriles to quinazolin-4(3H)-ones involving reduction, formylation, hydrolysis and cyclization is reported. These quinazolinones have been used for making in economical way the anticancer drug molecules gefitinib (Iressa®) and erlotinib HCl (Tarceva®).