M. Mahdavi, M. Asadi, Mina Saeedi
Nov 12, 2012
Citations
0
Influential Citations
28
Citations
Journal
ChemInform
Abstract
Novel imidazo[2,1-b]thiazol-5-amine derivatives were synthesized by a one-pot, four-component reaction of 2-bromoacetophenone derivatives, aromatic aldehydes, thiourea, and isocyanides in the presence of ammonium chloride (NH4Cl) in toluene under reflux conditions. Moderate to good yields resulted and the reaction showed tolerance toward a range of aromatic aldehydes with electron-donating and electron-withdrawing substituents on either para or ortho positions.