V. M. Muzalevskiy, Zoia A. Sizova, K. Belyaeva
Oct 1, 2019
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0
Influential Citations
10
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Journal
Molecules
Abstract
The reaction of pyridines with trifluoroacetylated acetylenes was investigated. It was found that the reaction of various pyridines with two molecules of CF3CO-acetylenes proceeds under mild metal-free conditions. As a result, efficient stereoselective synthesis of 3-arylethynyl-3-trifluoromethyl-1,3-oxazinopyridines was elaborated. Target heterocycles can be prepared in up to quantitative yields.