M. Nabati, M. Mahkam
Jun 1, 2014
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Journal
Iranian Chemical Communication
Abstract
2,6-Diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to over-alkylations, we earn a mixture of amino products. Consequently, they aren't selective in the case of secondary amines preparation. Also, the synthesis of secondary amines is a problematic field in organic chemistry. In this research, 2,6-diaminopyridine N-methylatedselictivity was done from reaction with sodium azide and orthoformic ester in low time with good yields.