Jinchu Liu, M. Cameron, Scott Hoerrner
May 31, 2007
Citations
0
Influential Citations
3
Citations
Journal
Organic Process Research & Development
Abstract
An efficient one-pot process for the preparation of pure (R)-N-[3-(4-iodophenyl)-2-oxo-5-oxazolidinyl]methylacetamide 1 from the mesylate 2b in 91% yield has been developed. The one-pot process makes use of commercially available sodium diformylamide 3 and avoids the use of highly hazardous reagents, simplifies workup procedures, and precludes detrimental impurity issues.