Chunjian Liu, E. Iwanowicz
Feb 10, 2003
Citations
0
Influential Citations
10
Citations
Journal
Tetrahedron Letters
Abstract
1,2,4-Triazole-3,5-diamine derivatives were synthesized in moderate to high yields in one-pot reaction from the corresponding isothiocyanates, mono-substituted hydrazines, and sodium hydrogencyanamide, in the presence of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride. Typically, two target compounds were obtained, but high regioselectivities to one isomer were observed when aromatic and sterically bulky hydrazines were used. A number of examples with a detailed representative procedure are given.