K. Kobayashi, Y. Yokoi, T. Komatsu
Nov 27, 2010
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron
Abstract
Abstract An efficient one-pot method for the synthesis of 4-monosubstituted and 4,4-disubstituted 1,4-dihydro-3,1-benzoxazine-2-thiones has been developed. Treatment of 2-bromophenyl isothiocyantes with butyllithium in THF at −78 °C generates 2-lithiophenyl isothiocyanates, which are allowed to react with various carbonyl compounds, including aldehydes, ketones, and butanolide, to give the corresponding desired products in moderate to good yields.