Wang Yu-ling
2008
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Journal
Chinese Journal of Synthetic Chemistry
Abstract
2,4,6-Trichloroquinazoline(2a) or 2,4-dichloro-6-nitroquinazoline(2b) was synthesized by the condensation of urea with 2-amino-5-chlorobenzoic acid(1a) or 2-amino-5-nitrobenzoic acid(1b) in the presence of phosphorus pentachloride in one-pot reaction.The structures were characterized by 1H NMR and ESI-MS.The optimal reaction conditions of synthesizing 2a in yield of 41% were follows: 1a was 2.5 mmol;n(1a) ∶n(PCl5) ∶n(urea) was 1.0 ∶6.0 ∶2.2;reflux time was 1.0 h.