Li Han-wei
2009
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Journal
Applied Chemical Industry
Abstract
2,4-Difluorophenylacetonitrile was synthesized from 2,4-difluorobenzaldehyde by reduction with KBH4 in water,followed by chlorination and cyanation in the water-carrying agent in one-pot.The effect of the different types of the reductant and water-carrying agent on the yield was investigated.The experimental result showed that the optimal condition was as follows:the molar ratio of 2,4-difluorobenzaldehyde,potassium borohydride,thionyl chloride and sodium cyanide was 1 ∶0.36 ∶1.26 ∶1.35,toluene was used as the water-carrying agent and the solvent of chlorination and cyanation,temperature of cyanation was 90 ℃,time was 3 h,the total yield was 62.1%.The improved synthetic process is practical and easy to be scaled up.