A. Tikad, S. Routier, M. Akssira
Nov 25, 2009
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0
Influential Citations
17
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Journal
Organic & biomolecular chemistry
Abstract
An efficient and original synthesis of various 2,4-disubstituted pyrido[3,2-d]pyrimidines is reported. One-pot di(het)arylation and diamination approaches were used to obtain highly functionalized products in very good yields. The two one-pot processes were compared to their step-by-step related synthesis. Both routes started from 2,4-dichloropyrido[3,2-d]pyrimidine and included a chlorine discrimination during the first reaction.