Wensheng Zhang, Chun-xiang Kuang, Qing Yang
2009
Citations
0
Influential Citations
5
Citations
Journal
Zeitschrift für Naturforschung B
Abstract
One-pot simultaneous debrominative decarboxylation and sulfamation of anti-2,3-dibromo-3-(4- chlorosulfonylphenyl)propanoic acid in DMF (for alkylamines) or DMF-pyridine (1/1, for arylamines) using a diverse range of alkyl and aryl amines under microwave irradiation stereoselectively afforded intermediate (Z)-4-(2-bromovinyl)benzenesulfonamides. The intermediates, without isolation and purification, were treated with EtONa to give the desired 4-ethynylbenzenesulfonamides. Graphical Abstract Efficient One-pot Synthesis of 4-Ethynylbenzenesulfonamides