P. Baraldi, Asier Unciti Broceta, M. J. P. D. L. Infantas
Sep 16, 2002
Citations
0
Influential Citations
17
Citations
Journal
Tetrahedron
Abstract
Abstract The synthesis of a number of new 6-alkoxy-8,9-(disubstituted)purines has been accomplished by the cyclization of the corresponding intermediate 5-amino-4-chloro-6-(alkylamino)pyrimidines promoted by alkoxides and various N , N -dimethyl amides, where the latter act as solvent–reagents. By this three-component condensation reaction we are able to introduce an alkyl group in the 8 position of the purine ring with the concomitant nucleophilic replacement of the 6-chloro group with an alkoxy moiety.