Nasrin Karami Hezarcheshmeh, J. Azizian
Nov 28, 2021
Citations
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Influential Citations
10
Citations
Journal
Polycyclic Aromatic Compounds
Abstract
Abstract In this research a new derivatives of 3,3,5-trichloroisatins and 3,3-dichloroisatins were synthesized in good yields using catalyst-free one-pot reaction of isatins or N-alkylisatines, triphenylphosphine and carbon tetrachloride in acetonitrile at room temperature. Because of existing isatin core in synthesized compounds, the antioxidant activity was investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and comparing the results with synthetic antioxidants (TBHQ and BHT). Easy, simple, fast and new procedure are the some advantages of this study. Graphical Abstract Highlights Heterocyclic system carrying indolin-2-one moiety has drawn tremendous interest of researchers in the area of synthetic organic and medicinal chemistry. During past decades, modifications mainly been made at the C-3 position of indolin-2-one and numerous compounds have been reported as drugs for treating various kinds of diseases. This easy separation of products with high yields and short time of reaction makes this protocol attractive and useful as an industrially viable.