Hong Zhang, Jinhai Shen, Guolin Cheng
Jan 17, 2018
Citations
0
Influential Citations
16
Citations
Journal
Organic letters
Abstract
A highly atom-efficient "one-pot" protocol has been developed to construct multisubstituted 2-hydroxy-benzo[b][1,4]oxazins starting from N-(2-hydroxylaryl)enaminones. This procedure comprises a PIDA-mediated intramolecular iminoenol tautomer trapping reaction, followed by Et3N-promoted aerobic oxidative ring construction. In particular, an O2 molecule from air served as the oxygen source of the hydroxyl group in the titled products. This reaction proceeded smoothly at room temperature under air atmosphere and metal-free conditions.