Tulshiram Dalmal, K. Appalanaidu, U. Kosurkar
Apr 1, 2014
Citations
0
Influential Citations
14
Citations
Journal
European Journal of Organic Chemistry
Abstract
A highly efficient method for the synthesis of 2-imino-4-(trifluoromethyl)thiazolidin-4-ol derivatives has been achieved by the one-pot, three-component reactions of primary amines, aryl isothiocyanates, and 3-bromo-1,1,1-trifluoropropanone. The reactions go via symmetrical and unsymmetrical thiourea intermediates. Subsequent reactions of the products allow the synthesis of various scaffolds, including isoxazoles, triazoles, and propargylamine derivatives.