Parameshwara Chary Jilloju, P. Shyam, C. Raju
Feb 11, 2021
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Journal
Polycyclic Aromatic Compounds
Abstract
Abstract An efficient rapid synthesis of a new class of diversely functionalized 6-phenyl-3-(1H-pyrazol-1-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives (4a–q) is described via a facile one-pot, three-component cascade reaction with high yields. It is a multi-functional cyclization reaction to form two new heterocycles. The structures of newly formed compounds were confirmed by using spectral and analytical studies. Simple reaction conditions, the good isolated yield of the product, and no column chromatographic purification are attractive features of the present protocol. Further, the newly synthesized compounds were screened for anti-microbial activity and molecular docking interactions.