Maruti B. Yadav, K. Lim, Jong Su Kim
Feb 16, 2021
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple and efficient synthetic protocol for the synthesis of methyl 4-(4-chlorophenyl)-5,7-dioxo-1-phenyl-1,4,5,6,7,8-hexahydropyrazolo [4′,3′:5,6] pyrano[2,3-d] pyrimidine-3-carboxylate derivatives via a one pot four-component reaction catalyzed by l -Proline has been successfully developed. This new protocol produces pyrano pyrimidine carboxylate derivatives in good to excellent yields, with operational simplicity. The remarkable features of this methodology are high yields, metal-free catalyst, easy work-up procedure, and a greener method that avoids toxic catalyst and hazardous solvents.