W. Su, Tsung-Ping Lin, Kaung-Min Cheng
Jul 1, 2010
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0
Influential Citations
27
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Journal
Journal of Heterocyclic Chemistry
Abstract
A ‘‘one-pot’’ method for the synthesis of N-(1,3-diphenyl-1H-pyrazol-5-yl)amides was developed by cyclization of benzoylacetonitrile (1) and phenylhydrazine in neat condition followed by acylation. The corresponding N-(1,3-diphenyl-1H-pyrazol-5-yl)amides were provided in good to excellent yields (70– 90%). The significant advantages of the new synthetic method are excellent yields and simple work-up procedure without isolation and purification of intermediary 5-amino-1,3-diphenyl pyrazol (2).