A. Darehkordi, Mahin Ramezani
Feb 11, 2017
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Influential Citations
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Quality indicators
Journal
Molecular Diversity
Abstract
A new class of (2R,4S)-N-aryl-4-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxamide compounds was synthesized by a facile one-pot reaction of trans-4-hydroxy proline and trifluoroacetimidoyl chlorides in the presence of $$\hbox {TiO}_{2}$$TiO2-nanoparticles as a catalyst and sodium bicarbonate as a base. Synthesized compounds showed cytotoxicity with $$\hbox {IC}_{50}$$IC50 values of 15.3–70.3 $$\upmu \hbox {M}$$μM against K562 (Homo sapiens, human) cells. The results of the study provide a valuable method for one-pot synthesis of trans-4-hydroxy proline-based N-(2,2,2-trifluoroacetylated) compounds. Also, these compounds show significant pharmaceutical activities as antibacterial and antifungal reagents.Graphical Abstract