Parivash Jahanshahi, M. Mamaghani, Fereshteh Haghbin
Mar 5, 2018
Citations
0
Influential Citations
19
Citations
Journal
Journal of Molecular Structure
Abstract
Abstract Novel (1-methyl-1H-pyrrol-2-yl)-[2,3-d]pyrimidine derivatives were synthesized chemoselectively in good to high yields (81–90%) and short reaction times (7–14 min) by hydroxyapatite-encapsulated-γ-Fe2O3 supported sulfonic acid ([γ-Fe2O3@HAp-SO3H]) catalyzed condensation of 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile, 6-amino-2-(alkylthio)pyrimidin-4(3H)-one and various aromatic aldehydes. The easy work-up of the products, rapidity, high efficiency and recyclability of the catalyst are advantages of this protocol. The antibacterial activity of the newly synthesized products was investigated. Some of the products showed encouraging activity.