A. Gioiello, A. Khamidullina, M. C. Fulco
Nov 4, 2009
Citations
0
Influential Citations
25
Citations
Journal
Tetrahedron Letters
Abstract
A facile one-pot procedure for the synthesis of pyrazole-5-carboxylates by 1,3-dipolar cycloaddition of ethyl diazoacetate is described. Cycloadditions with α-methylene carbonyl compounds utilizing 1,8-diazabicyclo[5.4.0]undec-7-ene as base and acetonitrile as solvent provide pyrazoles with excellent regioselectivity and good yields. The reaction was found to proceed by a domino 1,3-dipolar cycloaddition-water elimination.