Seyedeh Bahareh Azimi, J. Azizian
Apr 13, 2016
Citations
0
Influential Citations
5
Citations
Journal
Synlett
Abstract
We present a one-pot method for the synthesis of 2,3-dihydroquinazoline-4(1H)-ones. The three-component reaction between isatoic anhydride, primary amines, and dialkyl acetylenedicarboxylates in the presence of N-sulfonic acid pyridinium chloride under solvent-free conditions affords the corresponding alkyl 2-[(alkoxycarbonyl)methyl]-1,2,3,4-tetrahydro-3-alkyl-4-oxo-quinazoline-2-carboxylates in excellent yields.