M. Tada, A. Oikawa, R. Iwata
Nov 1, 1989
Citations
0
Influential Citations
19
Citations
Journal
Journal of Labelled Compounds and Radiopharmaceuticals
Abstract
A rapid, one-pot synthesis of 2-deoxy-2-[18F]fluoroacetamido-D-glucopyranose (N-[18F]fluoroacetyl-D-glucosamine) (1) starting from [18F]fluoride and ethyl bromoacetate is described. The synthesis was accomplished by a combination of halogen exchange, alkaline hydrolysis, and condensation. [18F]Fluoride was produced by the 18O (p, n) 18F nuclear reaction using the cyclotron. The total synthesis time, the radiochemical yield, and purity of (1) are ca. 90 min, ca. 9.1%, and >98%, respectively. Sugar (1) showed the diagnostic tumor-imaging activity.