Tongshou Jin, Ai-Qing Wang, Xin Wang
Apr 1, 2004
Citations
0
Influential Citations
145
Citations
Quality indicators
Journal
Synlett
Abstract
Abstract: An efficient and convenient approach to the synthesisof 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4 H -5,6,7,8-tetra-hydrobenzo[ b ]pyran derivatives using hexadecyltrimethyl ammoni-um bromide (HTMAB) as the catalyst (10 mol%) is described. Thismethod provides several advantages such as neutral conditions,high yields and simple work-up procedure, in addition water waschosen as a green solvent. Key words: tetrahydrobenzo[ b ]pyran, hexadecyltrimethyl ammo-nium bromide, aqueous media With increasing environmental concerns, more and morechemists are devoted to the area of ‘green synthesis’which means the reagents, solvent and catalyst are en-vironmentally friendly. In modern organic chemical re-search, Wender defined the ‘ideal synthesis’ as one inwhich the target components are produced in one step, inquantitative yield from readily available and inexpensivestarting materials in resource-effective and environmen-tally acceptable process. 1 The one-pot multicomponentcondensations represent a possible instrument to performa near ideal synthesis because they possess one of theaforementioned qualities, namely the possibilities ofbuilding-up complex molecules with maximum simplicityand brevity.