S. Sivakumar, Selvaraj Kanchithalaivan, R. Kumar
Jul 22, 2013
Citations
0
Influential Citations
15
Citations
Journal
RSC Advances
Abstract
A library of novel 2-(1H-indol-3-yl)-6-(methylamino)-5-nitro-4-aryl-4H-pyran-3-carbonitriles and 6-(methylamino)-4-(aryl)-5-nitro-2-phenyl-4H-pyran-3-carbonitriles were synthesized in excellent yields via domino one-pot three-component reactions of 3-(1H-indol-3-yl)-3-oxopropanenitrile or benzoylacetonitrile, aromatic aldehydes and (E)-N-methyl-1-(methylthio)-2-nitroethenamine respectively. This reaction presumably occurs via domino Knoevenagel condensation–Michael addition–intramolecular O-cyclization sequence of reactions. The significant advantages of this reaction include one-pot process, simple work-up procedure, excellent yields and no column chromatographic purification.