Pravinkumar N. Sable, S. Ganguly, P. Chaudhari
Jul 1, 2014
Citations
0
Influential Citations
17
Citations
Journal
Chinese Chemical Letters
Abstract
Abstract A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction of acetyl acetone 1 , phenyl isothiocynate 2 and 2-chloromethyl derivatives 3a – 3c in the presence of potassium carbonate afforded the target compounds, namely ethyl 2-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-2-oxoacetate derivatives 4a – 4e , ethyl 3-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-3-oxopropanoate derivatives 4f – 4i , di((4-acetyl-3-methyl-5-phenylamino)thiophen-2-yl)ketone derivatives 4j – 4n in reasonable overall yields. The synthesized compounds were screened for antimicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.