Z. Fang, Di Fang, Jing Zheng
Jun 1, 2013
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Journal
Journal of Chemical Research
Abstract
Three-component reactions of ethyl 2-methylthio-4-[(triphenylphosphanylidene)amino] thiazole-5-carboxylate with aromatic diisocyanates and secondary amines produced novel bis[2-methylthio-7-oxothiazolo[4,5-d]pyrimidin-6(7H)-yl]benzenes in the presence of EtONa in 67–93% yields. This method provides an effective synthesis of nitrogen-containing heterocycles with the advantages of mild reaction conditions, simple operation and good yields. The structures of the products were confirmed by 1H NMR, IR, MS and elemental analysis.