Ya-Shan Hsiao, Bharat D. Narhe, Ying Chang
Sep 9, 2013
Citations
0
Influential Citations
19
Citations
Journal
ACS combinatorial science
Abstract
A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.