Xuguang Yin, Yamei Guo, Cuibo Liu
Sep 2, 2015
Citations
0
Influential Citations
13
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A simple and efficient route for the construction of 2,3,5,6-tetrafluorobenzonitrile-substituted dithiocarbamic acid esters via selective C–F bond cleavage of pentafluorobenzonitrile is proposed. This procedure combines the nucleophilic addition of various nitrogen anion to C S moiety and the nucleophilic substitution of the in situ formation of thiocarboxylate anion with pentafluorobenzonitrile in one-pot and enables a rapid access to the products in moderate to excellent yields. The synthesized product is a promising intermediate for further transformation.