M. Fujita, H. Egawa, Chiba Katsumi
Nov 1, 1997
Citations
0
Influential Citations
3
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
The one-pot reaction of ethyl 1-cyclopropyl-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (6) with tert-butyl acetoacetate gave 3-tert-butyl 7-ethyl 9-cyclopropyl-4-fluoro-6,9-dihydro-2-methyl-6-oxofuro[3,2-h]quinoline-3,7-dicarboxylate (5). This regioselective cyclization was rationalized by the Hard and Soft Acids and Bases principle. By use of a similar furan-forming reaction, we prepared 2-(amino-methyl)furo[3,2-h]quinoline-7-carboxylic acid 4. Compound 4 showed weak antibacterial activity.