Michael V. Tarasca, Cassidy J. Tomlinson, Pavel Gris
Sep 7, 2022
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Journal
Synthesis
Abstract
A one-step, gram-scale synthesis of caffeine-d9 was achieved using xanthine and CD3I. The reaction proceeds at room temperature using dimsyl sodium as base and THF as solvent, and conducting the reaction on a 1 g scale gave caffeine and caffeine-d9 in 77% and 86% yield, respectively, after recrystallization.