A. Jalilian, H. Afarideh, R. Najafi
2000
Citations
0
Influential Citations
4
Citations
Journal
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
Abstract
PURPOSE Cholesteryl 4-[(18)F]-fluorobenzoate, a potential radiotracer used for adrenal and ovarian imaging, was prepared in no-carrier-added form from cholesteryl 4-N,N,N-trimethylanilinium trifluoromethanesulfonate. METHODS The reaction was performed in one step using Kryptofix2.2.2/[(18)F], carbonate as the counter ion and dimethyl sulfoxide as the solvent at 110 degrees C. Purification was performed using commercially available C(18) and Si Sep-Paks. RESULTS Column purification afforded the desired compound in 75-85 % radiochemical yield (EOS) with a specific activity about 74 KBq/mmole in about 20 minutes, with greater than 95% radiochemical and chemical purity (HPLC and TLC analysis). CONCLUSIONS This compound was prepared through a novel method which can be easily performed at distant locations from the main radionuclide production centers using Sep-Paks. The biodistribution of this compound in mice was confirmed to be similar to that reported in the literature.