T. Kojima, F. Nagasaki, Y. Ohtsuka
May 1, 1980
Citations
0
Influential Citations
11
Citations
Journal
Journal of Heterocyclic Chemistry
Abstract
A series of 5,6-disubstituted 3-alkoxypyrazine-2-carbonitriles (2a-i) were prepared from 5,6-disubstituted pyrazine-2,3-dicarbonitriles (1a-d) by direct substitution with alcohols. Treatment of 1 with amines gave either pyrrolopyrazines (3a,b) or substitution products (4,5). In a low temperature range, 1 afforded imidates and related compounds (6–11). The preference among these reactions depended on the 5,6-substituents and on the reaction conditions.