R. N. Neves Filho, Diana C B da Silva-Alves, Janaína V Dos Anjos
Mar 26, 2013
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0
Influential Citations
5
Citations
Journal
Synthetic Communications
Abstract
Abstract A simple and straightforward synthesis of 3-aryl-5-hydroxyalkyl-1,2,4-oxadiazoles is described. The reaction among arylamidoximes, ethyl glycolate or ethyl lactate, and potassium carbonate in refluxing toluene afforded the desired 1,2,4-oxadiazoles in moderate to good yields. The synthesis has been accomplished in a single step, avoiding protection–deprotection protocols. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file. GRAPHICAL ABSTRACT