K. Izumi, M. Kabaki, M. Uenaka
Oct 10, 2007
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Influential Citations
9
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Journal
Organic Process Research & Development
Abstract
Practical one-step synthesis of 5-(4-fluorobenzyl)-2-furyl methyl ketone was accomplished by Friedel–Crafts benzylation of 2-furyl methyl ketone with 4-fluorobenzyl chloride in the presence of ZnCl2. Two reaction conditions and their work-up procedures are reported. The first utilizes an anhydrous condition in dichloromethane, providing a convenient procedure for the isolation of the product. The second involves an aqueous condition, which offers a large-scale ecological and safe manufacturing process.