M. Chao, A. Hao, Hui Wang
Feb 26, 2009
Citations
0
Influential Citations
3
Citations
Journal
Organic Process Research & Development
Abstract
A convenient one-step process for the preparation of methyl 2-benzamidomethyl-3-oxobutanoate (1), a raw material used in the synthesis of (2R,3R)-3-((R)-1-(tert-butyldimethylsilyloxy)ethyl)-2,3-dimethyl-4-oxoazetidin-2-yl acetate (2), a key intermediate for carbapenem synthesis is reported. The process is carried out under mild reaction conditions and is amenable to large-scale synthesis.