Taoda Shi, Lynn K Kaneko, M. Sandino
Dec 14, 2018
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0
Influential Citations
7
Citations
Journal
ACS sustainable chemistry & engineering
Abstract
Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that previously required a three step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S8 and formamide. The reported reaction is characterized by step economy, reduced catalyst loading and easy purification.