T. Voelker, T. Ewell, Jean Joo
Jan 29, 1998
Citations
0
Influential Citations
19
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The potential for the o-nitrobenzyl group as an alternative nitrogen protecting group for various indoles, benzimidazole, and 6-chlorouracil was determined. Treatment of the appropriate NH containing substrate with LiH or NaH in DMF followed by o-nitrobenzyl bromide afforded reasonable yields of N -alkylated products. To effect removal of this group, simple photolysis with 300 nm light afforded good yields of starting substrate.