Thomas Owley, Jeff Salt, Stephen J. Guter
Oct 29, 2006
Citations
5
Influential Citations
86
Citations
Quality indicators
Journal
Journal of Child and Adolescent Psychopharmacology
Abstract
Background: This pilot study examined the effectiveness of memantine hydrochloride in improving cognitive functioning and behavioral symptoms in children with pervasive developmental disorders (PDDs). Method: Subjects aged 3–12 years inclusive were enrolled in this 8-week, open-label study. Expressive and receptive language, nonverbal IQ, and nonverbal memory measures were administered at baseline and after 8 weeks of treatment with 0.4 mg/kg of memantine hydrochloride. Throughout the study, the Aberrant Behavior Checklist (ABC) was sent in weekly by parents as a measure of behavioral change. Results: Twelve of 14 subjects completed the study. Significant improvement from baseline was noted on the memory test (Children’s Memory Scale Dot Learning Subtest). There were no significant differences from baseline on measures of expressive or receptive language or nonverbal IQ. There were significant improvements on a number of ABC subscales, including hyperactivity, lethargy, and irritability. There were no ove...