M. V. D. Heuvel, A. D. Cuiper, H. V. D. Deen
Mar 3, 1997
Citations
0
Influential Citations
32
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Kinetic resolution of 6-acetyloxy-2 H -pyran-3(6 H )-one ( 1 ) is achieved by immobilized lipase PS on Hyflo Super Cell in organic solvents. Transesterification in hexane/n-butanol yields enantiomerically pure R -(−)-6-acetyloxy-2 H -pyran-3(6 H )-one, whereas esterification of 6-hydroxy-2 H -pyran-3(6 H )-one ( 2 ) with vinyl acetate by immobilized lipase PS gives the S -enantiomer with e.e.'s up to 76%.